Ensuring the Best Start for Your Embryos
Controversial Opinions and Clarifications:
Embarking on the journey of assisted reproductive technologies can be both exciting and daunting for intended parents. Amidst the myriad of decisions to be made, the question of whether to opt for Preimplantation Genetic Screening (PGS) or Preimplantation Genetic Diagnosis (PGD) adds another layer of complexity. For many intended parents, understanding the nuances of these procedures can be challenging. Let us clarify the differences and when each procedure is recommended.
What is PGS and Who Can Benefit:
PGS, recently known as PGT-A (Pre-implantation Genetic Testing), is a procedure performed on embryos after 5-6 days from fertilization, specifically at the blastocyst stage. It aims to determine the chromosomal normalcy of embryos, crucial for a healthy pregnancy. PGS is done through a Trophectoderm biopsy. It is performed with two technological achievements – Next-Generation Sequencing (NGS) and an array-based method. It offers a harmonious approach, ensuring that the genetic composition is not just understood but celebrated. Every chromosome, every gene, becomes a part of this symphony, resonating with the promise of a future yet to unfold.
Why consider PGS? As the ticking hands of time affect us all, it is crucial to note that the risk of chromosomal abnormalities surges with the mother’s age. Beyond 35, the recommendation to consider PGS becomes resounding. But here is a revelation – even if you are below 35 or using donor eggs, the specter of aneuploidy embryos looms. PGS acts as a safeguard, a careful filter ensuring you do not transfer embryos with abnormal chromosome counts.
The benefits? Having PGS tested embryos transferred increases implantation chances and results to higher success rates. Increased chances of embryo implantation mean a more secure start for your little one, like finding the perfect spot in a welcoming home. It is not just about numbers; it is about creating the best conditions for that tiny miracle to thrive. PGS significantly lowers miscarriage risks.
Worried about the procedure impacting embryo quality? Fear not. In the hands of an experienced embryologist, PGS is a safe voyage into securing the healthiest embryos. In the delicate hands of an experienced embryologist, PGS is not just a test; it’s a guardian of the purity of your dreams. It is a journey, a voyage into the depths of your hopes, navigating the delicate intricacies of life creation with expertise and finesse. Each embryo is cradled in the hands of those who have mastered the delicate dance between precision and compassion.
Thinking globally? If your journey involves overseas clinics or a change of scenery for embryo transfer, opt for PGS on fresh embryos. While it is still possible to be performed afterwards, freezing and thawing may slightly alter quality, a nuance worth considering.
And the wait for results? Typically 2-4 weeks, we ship biopsied materials to external genetic labs.
Navigating PGS Results:
What about the dreaded abnormality revelation? Before dismissing embryos, seek solace in a genetic specialist’s counsel. It is not a dead end; it is a possibility for expert guidance. And remember, PGS doesn’t eradicate all genetic disorders, so if certain hereditary conditions haunt your family tree, a separate path awaits.
What is PGD and When to Consider:
Now, let us turn our gaze to PGD – Preimplantation Genetic Diagnosis. Similar to PGS, but with a nuanced goal – ruling out specific genetic disorders. If you, your partner, or your donor share a carrier status for disorders like Fragile X Syndrome, Sickle Cell Anemia, Thalassemia, Cystic Fibroses, Spinal Muscle Atrophy, Tay-Sachs Disease etc, PGD steps into the spotlight. For PGD, along with the biopsied materials from the embryos, blood samples are essential, a small sacrifice for the holistic health report that follows.
Important Considerations for both PGS and PGD:
- They both provide details on gender, allowing you to prioritize the desired gender when transferring embryos.
- Expect that, on rare occasions, the laboratory may mention in issued results that the normalcy of a specific embryo was not detected due to an insufficient amount of biopsied materials. This happens rarely and is individual; the embryology team should not be blamed for this.
- Due to the high number of procedures at the laboratory, a slight delay in issuing results may be expected.
- If you are considering guaranteed programs, PGS/PGD come with additional payment, and the gender of the baby is not guaranteed. You can prioritize desired gender embryos for transfer, but under the terms of guaranteed programs, all existing embryos shall be used before conducting the following fresh IVF cycle.
- With PGS/PGD tested embryos, it is strongly recommended to transfer only one embryo.
